Will Peyton Manning and the pass-happy Broncos' attack move the ball against Seattle's supremely confident secondary? Can Denver's less than stellar defense stop Seattle's offense? Will the weather in East Rutherford matter?
Vitals, a Lyndhurst-based doctor selection site, has an entirely different criteria. The company is ranking both teams based on the quality of doctors.
Call it the Doctors Bowl. Vitals is giving the nod to Seattle.
"Everyone knows that football players get hurt, but we're often unaware of the doctors who keep them healthy and get them back in the game," Vitals spokeswoman Rosie Mattio said via email.
The company, which maintains a database of American doctors and provides online reviews and ratings, based its prediction by examining four categories: experience, patient rating, academic credentials and awards.
While Broncos fans may ask for a second opinion, here is the breakdown:
The Seahawks win in experience — its doctors have an average of 17.4 years of medical experience compared with 13.25 at Denver — and awards — Seattle doctors have earned 18 peer and patient recognized awards, or 3.6 per physician. The Broncos have two recognitions per doctor for a total of eight.
The average patient rating given to doctors on both squads is 3.5 out of 4 though patients in Seattle tend to rate doctors more often. Seattle team doctors have an average of 5 ratings per doctor, compared with 3.75 ratings for Denver, according to Vitals.
The lone victory for Denver came in academic credentials. Their doctors' average medical school rating was 3.5, compared with 3.0 for schools attended by Seattle doctors.
Vitals, which employs more than 100 and reports 2012 revenue of about $10 million, according to Inc. magazine, stopped short of picking a final score.
Mattio decline the challenge, noting she is based in Seattle. When asked whether there will there be a Doctors Bowl II, she replied: "We're not sure if this will become an annual prediction ... maybe if we're right."